HSP70是一類分子伴侶，可以調(diào)控Tau、α-突觸核蛋白、TDP-43、朊蛋白和多聚谷氨酰胺蛋白的代謝進程，抑制神經(jīng)退行性疾病中錯誤折疊蛋白質(zhì)的聚集和毒性作用。
文獻引用：（12篇）Preparation of photothermal responsive and ROS generative gold nanocages for cancer therapy.
Chemical Engineering Journal.
DOI: 10.1016/j.cej.2021.129744
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Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling.
Bone Research.
PMID: 33431863
抗體介紹
Beclin-1是自噬中的重要角色，阿爾茲海默癥早期，Beclin-1在腦部病變區(qū)域中的表達(dá)是呈下降趨勢的，，研究表明該蛋白的表達(dá)會減少細(xì)胞內(nèi)外的淀粉樣病變，而表達(dá)減少則會增加神經(jīng)元內(nèi)淀粉樣蛋白的聚集。因此，增加beclin-1水平可能成為潛在的AD的治療方案。文獻引用：（20篇）
Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice.
Scientific Reports.
PMID: 28071754
文獻引用：（47篇）
RBM39 Alters Phosphorylation of c-Jun and Binds to Viral RNA to Promote PRRSV Proliferation.
Frontiers in Immunology.
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Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression.
Molecular Therapy-Nucleic Acids.
PMID: 32781430
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CDC42EP3 is a key promoter involved in the development and progression of gastric cancer.
Carcinogenesis.
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Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation，and Nrf2 activation in a toxic model combining hyperglycemia+Aβ1-42 peptide in rat hippocampal neurons.
Neurochemistry International.
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文獻引用：（1篇）
Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure micethrough targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways.
J Ethnopharmacol.
PMID: 31055001
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Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain.
J Neuroinflammation.
PMID: 30975172
