| 產(chǎn)品編號(hào) | bs-42424P |
| 英文名稱 | Recombinant mouse SKI protein, GST&His |
| 中文名稱 | 重組小鼠SKI蛋白 |
| 別 名 | C-SKI; v-SKI; Sloan-kettering viral oncogene homolog; Avian sarcoma viral (v ski) oncogene homolog; C oncogene; C ski; Ski oncogene; Ski oncoprotein; SKV; v ski avian sarcoma viral oncogene homolog; v ski sarcoma viral oncogene homolog; v-ski sarcoma viral oncogene homolog; SKI_MOUSE. |
| 克 隆 號(hào) | |
| 理論分子量 | 51.8 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Liquid |
| 濃 度 | >1mg/ml |
| 純 度 | >90% as determined by SDS-PAGE |
| 緩 沖 液 | 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc. SWISS: Q60698 Gene ID: 20481 SKI又稱SKI、SKV，經(jīng)研究發(fā)現(xiàn)SKI蛋白是刺激和誘發(fā)腫瘤生長(zhǎng)導(dǎo)致癌癥的關(guān)鍵蛋白質(zhì)之一，SKI蛋白主要通過阻止TGF-β蛋白發(fā)揮作用,當(dāng)TGF-β蛋白的信號(hào)傳導(dǎo)被SKI蛋白阻斷后，細(xì)胞就可能加速增值、生長(zhǎng)，最終導(dǎo)致癌癥發(fā)生。 有研究表明：c-ski可調(diào)節(jié)多種核因子的轉(zhuǎn)錄活性,參與神經(jīng)系統(tǒng)發(fā)育、造血細(xì)胞的增殖和分化、腫瘤發(fā)生、組織再生等多種生理病理過程，更詳細(xì)的作用機(jī)制還在進(jìn)一步研究之中。 |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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