| 產(chǎn)品編號(hào) | IHC0288H |
| 英文名稱 | Human PD-1 Ready-To-Use IHC Kit |
| 中文名稱 | 人程序性死亡1（CD279）即用型免疫組化試劑盒 |
| 別 名 | CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; PDCD1; SLEB2; hPD l; PD 1; programmed cell death 1; Protein PD 1 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE. SWISS: Q15116 Gene ID: 5133 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0288H (Human PD-1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0288H (Human PD-1 IHC Kit).
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