| 產(chǎn)品編號 | bs-1530R |
| 英文名稱 | Slc4a7 Rabbit pAb |
| 中文名稱 | 碳酸氫鈉協(xié)同轉(zhuǎn)運(yùn)蛋白4-A7抗體 |
| 別 名 | NBC3; NBCn1; Slc4a7; Nbc; Nbc2; Nbc3; Bicarbonate transporter; BT; NBC2; NBC3; S4A7; SBC2; SLC4A6; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Sodium bicarbonate cotransporter 3; Solute carrier family 4 member 7; Solute carrier family 4 sodium bicarbonate cotransporter member 7; solute carrier family 4, sodium bicarbonate cotransporter, member 7. |
| 研究領(lǐng)域 | 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)運(yùn)蛋白 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 140 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from rat Slc4a7 isoform 2: 1-100/1254 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Function: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity Subunit: Interacts with USH1C. Forms a complex with ATP6V1B1 and SLC9A3R1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2. Interacts with CFTR probably through SLC9A3R1/EBP50. Subcellular Location: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, stereocilium. Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells. Tissue Specificity: Expressed in aorta, ventricles, atrium, mesenteric artery, kidney, spleen, duodenum, jejunum, ileum, colon, lung, trachea, gastric fundus and pylorus, cerebrum, cerebellum, pancreas, liver, parotid gland, and epididymis. Expressed in the inner ear by cochlear outer and inner hair cells (at protein level). Highly expressed in testis and spleen. Also detected in heart, brain, lung, liver and kidney. Isoform 4 and isoform 5 are specifically expressed in kidney. Isoform 6 is specifically expressed in hippocampal neurons. Post-translational modifications: N-glycosylated. Similarity: Belongs to the anion exchanger (TC 2.A.31) family. Database links: Entrez Gene: 9497 Human Omim: 603353 Human SwissProt: Q9Y6M7 Human Unigene: 250072 Human SLC4A7屬溶質(zhì)性載體家族成員，是物質(zhì)轉(zhuǎn)運(yùn)和在能量傳遞中起到重要作用的蛋白。 |
