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Rabbit Anti-TRAP1/HSP75  antibody (bs-1446R)  
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產(chǎn)品編號 bs-1446R
英文名稱 Rabbit Anti-TRAP1/HSP75  antibody
中文名稱 熱休克蛋白75抗體
別    名 TRAP1; TRAP-1; Heat shock protein 75; Heat shock protein 75 kDa mitochondrial; HSP 75; HSP 90L; HSP75; HSP90L; TNF receptor associated protein 1; TNFR associated protein 1; TRAP 1; Tumor necrosis factor receptor associated protein; Tumor necrosis factor type 1 receptor associated protein; TRAP1_HUMAN.  
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Chicken,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 74kDa
細胞定位 細胞漿 線粒體
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HSP75: 501-650/704 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Function:
Chaperone that expresses an ATPase activity.

Subunit:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1.

Subcellular Location:
Mitochondrion.

Tissue Specificity:
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

Similarity:
Belongs to the heat shock protein 90 family.

SWISS:
Q12931

Gene ID:
10131

Database links:

Entrez Gene: 10131 Human

Entrez Gene: 68015 Mouse

Entrez Gene: 287069 Rat

Entrez Gene: 416666 Chicken

Entrez Gene: 514472 Cow

Omim: 606219 Human

SwissProt: Q2TBI4 Cow

SwissProt: Q12931 Human

SwissProt: Q9CQN1 Mouse

SwissProt: Q5XHZ0 Rat

Unigene: 30345 Human

Unigene: 123366 Mouse

Unigene: 144695 Rat



信號傳導(dǎo)(Signaling Intermediates)
HSP75/TRAP-1與TNF受體發(fā)生相互作用,可產(chǎn)生促進TNF的信號轉(zhuǎn)導(dǎo)。
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