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Rabbit Anti-ABCB5  antibody (bs-1604R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-1604R
英文名稱 Rabbit Anti-ABCB5  antibody
中文名稱 ATP結(jié)合蛋白家族5抗體
別    名 ATP-binding cassette sub-family B member 5; ABCB 5; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; EST422562; P glycoprotein ABCB5; ABCB5_HUMAN.  
Specific References  (6)     |     bs-1604R has been referenced in 6 publications.
[IF=6.022] Julia Riedl. et al. ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment. 2021 Mar 01  WB ;  Mouse.  
[IF=5.923] Anna Kusienicka. et al. Heme Oxygenase-1 Has a Greater Effect on Melanoma Stem Cell Properties Than the Expression of Melanoma-Initiating Cell Markers. Int J Mol Sci. 2022 Jan;23(7):3596  FC ;  Mouse.  
[IF=4.77] Kaushik, Gaurav, et al. "Honokiol inhibits melanoma stem cells by targeting notch signaling." Molecular carcinogenesis (2014).  WB ;  Human.  
[IF=0] Hardt, Olaf, et al. "SSEA4 AND ST3GAL2 AS CHEMOTHERAPEUTIC DRUG RESPONSE BIOMARKERS." U.S. Patent No. 20,150,316,556. 5 Nov. 2015.  FCM ;  Mouse.  
[IF=] Nandabalan K. NOVEL IMMUNOMODULATORY THERAPEUTIC STRATEGIES TARGETING TUMORS IN CANCER. US 2018 / 0134771 A1  ABCB5 inhibitor ;  
[IF=] Nandabalan K et al. NOVEL IMMUNOMODULATORY THERAPEUTIC STRATEGIES TARGETING TUMORS IN CANCER. US Patent App. 15/572,422, 2018  Other ;  Human.  
研究領(lǐng)域 腫瘤  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  糖蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABCB5: 841-883/1257 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

Function:
Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.

Similarity:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 2 ABC transporter domains.

SWISS:
Q2M3G0

Gene ID:
340273

Database links:

Entrez Gene: 340273 Human

Omim: 611785 Human

SwissProt: Q2M3G0 Human

Unigene: 404102 Human



產(chǎn)品圖片
Sample: Lane 1: Mouse B16 cell lysates Lane 2: Mouse Testis tissue lysates Primary: Anti-ABCB5 (bs-1604R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 89/138 kD Observed band size: 125 kD
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