| 產(chǎn)品編號 | bs-2394R |
| 英文名稱 | Rabbit Anti-CKLF antibody |
| 中文名稱 | 趨化素樣蛋白抗體 |
| 別 名 | C32; Chemokine-like factor; chemokine-like factor 1; chemokine-like factor 2; chemokine-like factor 3; chemokine-like factor 4; CKLF_HUMAN; CKLF1; CKLF2; CKLF3; CKLF4; CKLFSF2; HSPC224; transmembrane proteolipid; UCK-1; UCK1. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 細(xì)胞分化 淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Rabbit) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17kDa |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CKLF: 1-100/152 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011] Function: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10. Isoform 1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes. Subcellular Location: Isoform 1: Secreted. Isoform 2: Membrane; Multi-pass membrane protein. Isoform 4: Membrane; Multi-pass membrane protein. Tissue Specificity: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver. Similarity: Belongs to the chemokine-like factor family. Contains 1 MARVEL domain. SWISS: Q9UBR5 Gene ID: 51192 Database links: Entrez Gene: 51192 Human Entrez Gene: 75458 Mouse Omim: 607885 Human SwissProt: Q9UBR5 Human SwissProt: Q9DAS1 Mouse Unigene: 15159 Human Unigene: 81197 Rat CKLF（趨化素樣因子）是人類趨化素樣因子超家族CKLFSF（Chemokine-like Factor Super Family，趨化素樣因子超家族）中的一員，趨化因子能使細(xì)胞發(fā)生趨化運(yùn)動(dòng)的小分子細(xì)胞因子。趨化因子結(jié)構(gòu)和功能比較相似,分子量多在10-20kDa之間,對嗜中性粒細(xì)胞、淋巴細(xì)胞、單核細(xì)胞等多種細(xì)胞有趨化活性。 |
