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Rabbit Anti-ICAM1  antibody (bs-4617R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-4617R
英文名稱 Rabbit Anti-ICAM1  antibody
中文名稱 細胞間粘附分子-1(CD54)抗體
別    名 BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor.  
Specific References  (11)     |     bs-4617R has been referenced in 11 publications.
[IF=6.691] Yu-Chen Chen. et al. Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy. 2021 Jul 13  WB,IHC ;  Human.  
[IF=4.522] Zhao H et al. miR‐181a/b‐5p ameliorates inflammatory response in monocrotaline‐induced pulmonary arterial hypertension by targeting endocan. J Cell Physiol. 2019 Oct 21.  WB ;  Rat.  
[IF=4.36] Xiao Li. et al. Mechanism by which Huoxue Tongluo Qiwei Decoction improves the erectile function of rats with diabetic erectile dysfunction. J Ethnopharmacol. 2022 Jan;283:114674  WB ;  Rat.  
[IF=3.905] Fen Xu. et al. Lipoxin A4 and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway. Exp Cell Res. 2022 Mar;412:113025  IF ;  Rat.  
[IF=3.69] Ji-Sheng Wang. et al. Effect of leech-centipede medicine on improving erectile function in DIED rats via PKC signalling pathway-related molecules. J Ethnopharmacol. 2021 Mar;267:113463  WB ;  Rat.  
[IF=3.298] Zhongxiao Zhou. et al. Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats:. INT J IMMUNOPATH PH. 2022;():  WB ;  Rat.  
[IF=2.976] Peng?Y et al. Sonodynamic therapy improves anti?tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft. Oncol Rep.?2018 Oct;40(4):2163-2170.?  IHF ;  Mouse.  
[IF=2.17] Wang, Xiaoyu, et al. "Preliminary research of relationship between acute peritonitis and celiac primo vessels." Evidence-Based Complementary and Alternative Medicine 2013 (2013).  IHC-P ;  Rat.  
[IF=2.11] Kim et al. Effects of chondrocyte-derived extracellular matrix in a dry eye mouse model. (2015) Mol.Vi. 21:1210-23  WB ;  Mouse.  
[IF=1.26] Zhou et al. Ultrasound combined with targeted cationic microbubble-mediated angiogenesis gene transfection improves ischemic heart function. (2017) Exp.Ther.Me. 13:2293-2303  WB ;  Human.  
[IF=0.181] Li S et al. The Effect of YiQiFuMai on Ischemic Heart Failure by Improve Myocardial Microcirculation and Increase eNOS and VEGF Expression. International Journal of Clinical Medicine,2020 11, 84-100.  WB ;  Rabbit.  
研究領域 腫瘤  免疫學  信號轉(zhuǎn)導  干細胞  細胞膜受體  細胞粘附分子  細胞表面分子  糖蛋白  細胞類型標志物  淋巴細胞  t-淋巴細胞  b-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,GuineaPig)
產(chǎn)品應用 WB=1:500-2000,Flow-Cyt=1μg/Test,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ICAM-1: 180-250/532 <Extracellular>
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].

Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Subunit:
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Post-translational modifications:
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Similarity:
Belongs to the immunoglobulin superfamily. ICAM family.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P05362

Gene ID:
3383

Database links:

Entrez Gene: 3383 Human

Entrez Gene: 15894 Mouse

Entrez Gene: 25464 Rat

Omim: 147840 Human

Unigene: 643447 Human

SwissProt: P05362 Human

SwissProt: P13597 Mouse

SwissProt: Q00238 Rat

Unigene: 435508 Mouse

Unigene: 12 Rat




產(chǎn)品圖片
Sample: A549 Cell (Human) Lysate at 40 ug Primary: Anti-ICAM1 (bs-4617R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD
Sample: Raw264.7 cell (Mouse) Lysate at 40 ug Raji Cell (Human) Lysate at 40 ug Heart (Mouse) Lysate at 40 ug Thymus (Mouse) Lysate at 40 ug Primary: Anti-ICAM1 (bs-4617R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD
Blank control(blue): U937(fixed with 2% paraformaldehyde (10 min)) Primary Antibody: Rabbit Anti-ICAM1 antibody(bs-4617R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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