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Rabbit Anti-Lumican  antibody (bs-5890R)  
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產(chǎn)品編號(hào) bs-5890R
英文名稱 Rabbit Anti-Lumican  antibody
中文名稱 基膜聚糖蛋白抗體
別    名 Keratan sulfate proteoglycan lumican; KSPG lumican; LDC; LUM; LUM_HUMAN; Lumican; Lumican precursor; lumican proteoglycan; SLRR2D.  
Specific References  (3)     |     bs-5890R has been referenced in 3 publications.
[IF=14.593] Binbin He. et al. 3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration. Bioact Mater. 2022 Jan;:  IF ;  Rabbit.  
[IF=11.061] Shuo Jia. et al. Digital light processing-bioprinted poly-NAGA-GelMA-based hydrogel lenticule for precise refractive errors correction. BIOFABRICATION. 2023 Apr;:  IF ;  Human.  
[IF=4.925] Ruixing Liu. et al. Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty. INVEST OPHTH VIS SCI. 2023 Mar;64(3):9-9  FCM ;  Rabbit.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 35kDa
細(xì)胞定位 細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lumican: 61-160/338 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

Subcellular Location:
Secreted. extracellular space. extracellular matrix.

Tissue Specificity:
Cornea and other tissues.

DISEASE:
Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Contains 11 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

SWISS:
P51884

Gene ID:
4060

Database links:

Entrez Gene: 280847 Cow

Entrez Gene: 4060 Human

Entrez Gene: 17022 Mouse

Omim: 600616 Human

SwissProt: Q05443 Cow

SwissProt: P51884 Human

SwissProt: P51885 Mouse

Unigene: 406475 Human

Unigene: 18888 Mouse



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (rat retina tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Lumican) Polyclonal Antibody, Unconjugated (bs-5890R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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