| 產(chǎn)品編號(hào) | bs-6535R |
| 英文名稱 | Rabbit Anti-FOLH1B antibody |
| 中文名稱 | 細(xì)胞生長抑制蛋白26/前列腺特異性膜抗原樣蛋白抗體 |
| 別 名 | PSMAL; Cell growth inhibiting gene 26 protein; Folate hydrolase 1B; Folate hydrolase 2; Folate hydrolase pseudogene; FOLH2; FOLHP; GCP3; GCPIII; glutamate carboxypeptidase III; N acetylated alpha linked acidic dipeptidase; NAALADase; Prostate specific membrane antigen like protein; PSM; PSMA like; Putative folate hydrolase 1B; Putative N acetylated alpha linked acidic dipeptidase; FOH1B_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 信號(hào)轉(zhuǎn)導(dǎo) 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FOLH1B: 175-270/442 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Prostate cancer is the most frequently diagnosed cancer and the early detection of prostate cancer dramatically and efficiently reduces the observed mortality rate. Several proteins have been identified as specific markers of prostate cancer, and they may be useful as diagnostic indicators. PSA, prostate specific antigen, is the classical indicator for transformed prostate tissue; however, in addition to being upregulated in prostate cancer, PSA is also upregulated in non-malignant conditions, such as benign prostatic hyperplasia prostate. Conversely, STEAP (six-transmembrane epithelial antigen of the prostate), prostate carcinoma tumor antigen (PCTA-1) and prostate-specific membrane antigen (PSM) represent additional prostate-specific antigens that are overexpressed only in malignant tumors and therefore are more specific identifiers of malignancies. PSM is an integral membrane protein, and PCTA-1 is related to the galectin gene family, which mediate both cell-cell and cell-matrix interactions in a manner similar to the selectin subgroup of C-type lectins. STEAP is a serpentine transmembrane cell-surface tumor-antigen that is predicted to functions as a channel or transporter protein. In addition to prostate cancers, STEAP is also upregulated in bladder, colon and ovarian cancers. Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Exhibits a dipeptidyl-peptidase IV type activity. Subcellular Location: Cytoplasm Tissue Specificity: Kidney and liver. Not expressed in the prostate. Similarity: Belongs to the peptidase M28 family. M28B subfamily. SWISS: Q9HBA9 Gene ID: 219595 Database links: Entrez Gene: 219595 Human Omim: 609020 Human SwissProt: Q9HBA9 Human Unigene: 645352 Human |
