| 產(chǎn)品編號(hào) | bs-7041R |
| 英文名稱 | Rabbit Anti-phospho-Kidins220 (Ser918) antibody |
| 中文名稱 | 磷酸化220kDa蛋白激酶D相互作用蛋白抗體 |
| 別 名 | Kidins220 (phospho S918); Ankyrin repeat-rich membrane-spanning protein; arms; KDIS_HUMAN; Kidins220; Kinase D interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; rgd 619949. |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 心血管 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Rabbit,Pig,Cow,Chicken,GuineaPig) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 196kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human Kidins220 around the phosphorylation site of Ser918: QM(p-S)FD |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Function: ’Promotes a prolonged MAP-kinase signaling byneurotrophins through activation of a Rap1-dependent mechanism.Provides a docking site for the CRKL-C3G complex, resulting inRap1-dependent sustained ERK activation. May play an important rolein regulating postsynaptic signal transduction through thesyntrophin-mediated localization of receptor tyrosine kinases suchas EPHA4. In cooperation with SNTA1 can enhance EPHA4-inducedJAK/STAT activation. May play a role in neurotrophin- andephrin-mediated neuronal outgrowth and in axon guidance duringneural development and in neuronal regeneration (By similarity).Modulates stress-induced apoptosis of melanoma cells via regulationof the MEK/ERK signaling pathway. Subunit: nteracts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Canform a ternary complex with NGFR and NTRK1 and this complex isaffected by the expression levels of KIDINS220/ARMS. An increase inKIDINS220/ARMS expression leads to a decreased association of NGFRand NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZdomains. Interacts with EPHA4 and PRKD1 (By similarity). Subcellular Location: Membrane. Tissue Specificity: Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. Post-translational modifications: Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4.Phosphorylation at Ser-918 is induced by phorbol ester treatment.Phosphorylation by NTRK2 is induced by brain-derived neurotrophicfactor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 isinduced by nerve growth factor (NGF) (By similarity). Similarity: Contains 12 ANK repeats. Contains 1 KAP NTPase domain. SWISS: Q9ULH0 Gene ID: 57498 Database links: Entrez Gene: 57498 Human Entrez Gene: 77480 Mouse SwissProt: Q9ULH0 Human Unigene: 9873 Human Unigene: 250641 Mouse Unigene: 21470 Rat
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