| 產(chǎn)品編號(hào) | bs-8345R |
| 英文名稱(chēng) | Rabbit Anti-FGFR1OP antibody |
| 中文名稱(chēng) | FGFR1癌基因伴侶蛋白抗體 |
| 別 名 | FGFR1 oncogene partner; FGFR1OP; Fibroblast growth factor receptor 1 oncogene partner; FOP; FR1OP_HUMAN; OTTHUMP00000017612; OTTHUMP00000017613. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 生長(zhǎng)因子和激素 細(xì)胞類(lèi)型標(biāo)志物 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FOP/FGFR1OP: 151-250/399 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
FOP, is a 399 amino acid protein that localizes to the centrosome and contains one LisH domain. Expressed ubiquitously with highest expression in kidney, heart, muscle, colon, liver, testis and pancreas, FOP functions as a homodimer that interacts with EB1 and CEP350 and is essential for anchoring microtubules to centrosomes. Chromosomal aberrations that involve the FOP gene are associated with the pathogenesis of stem cell myeloproliferative disorder (MPD), a condition that is characterized by eosinophilia and myeloid hyperplasia and ultimately leads to acute myeloid leukemia. FOP is expressed as multiple isoforms that are produced by alternative splicing events. Function: Required for anchoring microtubules to the centrosomes. Subunit: Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1. Subcellular Location: Cytoplasm, cytoskeleton, centrosome. Note=Associated with gamma-tubulin. Tissue Specificity: Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. DISEASE: Note=A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity. Similarity: Belongs to the FGFR1OP family. Contains 1 LisH domain. SWISS: O95684 Gene ID: 11116 Database links: Entrez Gene: 11116 Human Entrez Gene: 75296 Mouse Omim: 605392 Human SwissProt: O95684 Human SwissProt: Q66JX5 Mouse Unigene: 487175 Human Unigene: 227250 Mouse Unigene: 166829 Rat |
