| 產(chǎn)品編號 | bs-11332R |
| 英文名稱 | Rabbit Anti-CNGB1 antibody |
| 中文名稱 | 環(huán)核苷酸門控陽離子通道蛋白CNG-1β抗體 |
| 別 名 | CNCG 4; CNCG2; CNCG3L; CNCG4; CNG 4; CNG channel 4; CNG channel beta 1; CNG4; CNGB 1; CNGB1; CNGB1B; Cyclic nucleotide gated cation channel 4; Cyclic nucleotide gated cation channel; Cyclic nucleotide gated cation channel beta 1; Cyclic nucleotide gated cation channel gamma; Cyclic nucleotide gated cation channel modulatory subunit; Cyclic nucleotide gated channel (photoreceptor) cGMP gated 3 (gamma) like; Cyclic nucleotide gated channel beta 1; GAR1; GARP; GARP2; Glutamic acid rich protein; RCNC2; RCNCb; RCNCbeta; RP45; 240 kDa protein of rod photoreceptor CNG channel; cGMP gated cation channel beta subunit; Truncated glutamic acid rich protein; Truncated rod photoreceptor cGMP gated channel beta subunit; Truncated rod photoreceptor cGMP-gated channel beta-subunit; CNGB1_HUMAN. |
| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學(xué) 干細胞 細胞粘附分子 細胞骨架 細胞外基質(zhì) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 140kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human truncated GARP: 851-950/1251 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Function: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Subunit: Heterooligomeric complex with CNGA1. Subcellular Location: Membrane; Multi-pass membrane protein. DISEASE: Defects in CNGB1 are the cause of retinitis pigmentosa type 45 (RP45) [MIM:613767]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily. SWISS: Q14028 Gene ID: 1258 Database links: Entrez Gene: 1258 Human Entrez Gene: 333329 Mouse Omim: 600724 Human SwissProt: Q14028 Human |
