| 產(chǎn)品編號 | bs-12104R |
| 英文名稱 | Rabbit Anti-PRR7 antibody |
| 中文名稱 | 突觸富含脯氨酸膜蛋白7抗體 |
| 別 名 | Proline rich protein 7; Proline-rich protein 7; Prr7; PRR7_HUMAN; Synaptic proline rich membrane protein; Synaptic proline-rich membrane protein; transmembrane adaptor protein 3; TRAP3. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 通道蛋白 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 31kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PRR7: 1-80/274 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
PRR7 (proline rich 7), also known as Synaptic proline-rich membrane protein, is a 269 amino acid protein expressed in postsynaptic density (PSD) of the forebrain, especially in hippocampus. The proline rich sequence for which the protein is named is characteristic of a region that is involved in protein-protein interactions, acting as a ligand for SH3, WW and EVH1 domains. As a single-pass type III membrane protein, evidence shows that PRR7 forms a postsynaptic membrane complex with PSD-95 and NMDAz1, suggesting its possible function in the modulation of neural activities. The expression pattern in brain also suggests that PRR7 is essential for synaptic formation or maturation, specifically in the cerebrum. Two isoforms of PRR7 exist as a result of an alternative splicing event. Subcellular Location: Membrane. Cell junction > synapse > postsynaptic cell membrane. Enriched in post-synaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. SWISS: Q8TB68 Gene ID: 80758 Database links: Entrez Gene: 80758 Human Entrez Gene: 432763 Mouse SwissProt: Q8TB68 Human SwissProt: Q3V0I2 Mouse Unigene: 534492 Human Unigene: 315457 Mouse Unigene: 162185 Rat |
