| 產(chǎn)品編號(hào) | bs-15446R |
| 英文名稱 | Rabbit Anti-HECTD1 antibody |
| 中文名稱 | E3連接酶抑制素受體抗體 |
| 別 名 | E3 ligase for inhibin receptor; E3 ubiquitin protein ligase HECTD1; E3 ubiquitin-protein ligase HECTD1; EULIR; HECD1_HUMAN; HECT domain containing protein 1; HECT domain-containing protein 1; HECTD1; KIAA1131. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 染色質(zhì)和核信號(hào) 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 289kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HECTD1: 2201-2300/2610 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
EULIR is a major component of the ubiquitin-proteasome system and plays a role in determining the specificity of ubiquitin conjugation. It is responsible for transferring ubiquitin to targeted substrates from an E2 ubiquitin-conjugating enzyme through the intermediate formation of a thiol ester with ubiquitin. Similar to a number of other E3 ubiquitin ligases, EULIR contains an N-terminal ankyrin repeat domain, a mind bomb (mib) domain and a C-terminal HECT (homologous to E6-AP C-terminus) domain. The HECT domain is responsible for the ubiquitin ligase activity, catalyzing polyubiquitination. EULIR is ubiquitously expressed throughout early development and is important for the complete and proper closure of the neural tube. Mutations in the gene encoding EULIR can result in neural tube defects. Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity). Subunit: Interacts with IGSF1. Similarity: Belongs to the UPL family. K-HECT subfamily. Contains 4 ANK repeats. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 1 MIB/HERC2 domain. SWISS: Q9ULT8 Gene ID: 25831 Database links: Entrez Gene: 25831 Human Entrez Gene: 207304 Mouse SwissProt: Q9ULT8 Human SwissProt: Q69ZR2 Mouse Unigene: 708017 Human Unigene: 249391 Mouse |
