| 產(chǎn)品編號(hào) | bs-13696R |
| 英文名稱 | Rabbit Anti-PARD6G antibody |
| 中文名稱 | PARD6G蛋白抗體 |
| 別 名 | PAR 6 gamma protein; par 6 partitioning defective 6 homolog gamma; PAR 6G; PAR6D; PAR6gamma; Partitioning defective 6 homolog gamma; PAR6G_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞分化 跨膜蛋白 細(xì)胞膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PARD6G: 4-100/376 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
PARD6G (partitioning defective 6 homolog gamma) is a 376 amino acid adaptor protein that is involved in cell polarization and asymmetrical cell division processes. PARD6G contains one OPR domain, one PDZ (DHR) domain and one pseudo-CRIB domain. The PDZ and pseudo-CRIB domains are required for interaction with Rho small GTPases. Through its complex formation with PARD3G, PARD6G participates in the linking of GTP-bound Rho small GTPases to atypical protein kinase C (PKC) proteins. This assembly is involved in formation of normal tight junctions at epithelial cell-cell contacts. When atypical PKC and PARD6G are expressed with a constitutively active RAC, the proteins colocalize to the membrane ruffles, which are structures that occur at the leading edge of polarized cells during movement. Though widely expressed, PARD6G is found at highest levels in adult and fetal kidney. Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Subunit: Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Subcellular Location: Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity). Tissue Specificity: Widely expressed, with a higher expression in fetal and adult kidney. Similarity: Belongs to the PAR6 family. Contains 1 OPR domain. Contains 1 PDZ (DHR) domain. Contains 1 pseudo-CRIB domain. SWISS: Q9BYG4 Gene ID: 84552 Database links: Entrez Gene: 84552 Human Omim: 608976 Human SwissProt: Q9BYG4 Human |
