| 產(chǎn)品編號 | bs-14487R |
| 英文名稱 | Rabbit Anti-ECO1 antibody |
| 中文名稱 | ECO1蛋白抗體 |
| 別 名 | A930014I12Rik; CTF; CTF7 homolog 1; CTF7, S. cerevisiae, homolog of, 1; ECO1; ECO1 homolog 1; ECO1, S. cerevisiae, homolog of, 1; EFO1; EFO1p; ESCO1; ESCO1_HUMAN; ESO1; ESO1 homolog 1; ESO1, S. pombe, homolog of, 1; Establishment factor like protein 1; Establishment factor ortholog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; Establishment of cohesion 1, S. cerevisiae, homolog of; establishment of sister chromatid cohesion N-acetyltransferase 1; hEFO1; HGNC:24645; KIAA1911; N acetyltransferase ESCO1; |
| 研究領(lǐng)域 | 細(xì)胞生物 染色質(zhì)和核信號 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 95kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ECO1: 351-450/840 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist. Function: Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. Subcellular Location: Nucleus. Chromosome. Nuclear at interphase, associated with chromosomes during mitosis. Tissue Specificity: Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle. Post-translational modifications: Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the acetyltransferase family. GCN5 subfamily. SWISS: Q5FWF5 Gene ID: 114799 Database links: Entrez Gene: 114799 Human Entrez Gene: 77805 Mouse Omim: 609674 Human SwissProt: Q5FWF5 Human SwissProt: Q69Z69 Mouse Unigene: 464733 Human Unigene: 210996 Mouse Unigene: 450684 Mouse |
