| 產(chǎn)品編號 | bs-16878R |
| 英文名稱 | Rabbit Anti-L3MBTL1 antibody |
| 中文名稱 | 致死因子惡性腦瘤樣蛋白1抗體 |
| 別 名 | H-L(3)MBT; H-l(3)mbt protein; KIAA0681; L(3)mbt protein homolog; L(3)mbt-like; L3MBT; L3MBTL1; Lethal(3)malignant brain tumor-like protein 1; Lethal(3)malignant brain tumor-like protein; LMBL1_HUMAN; RGD1307316. |
| 研究領(lǐng)域 | 腫瘤 神經(jīng)生物學(xué) 轉(zhuǎn)運(yùn)蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 84kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human L3MBTL1: 551-650/752 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010] Function: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. Subcellular Location: Nucleus. Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex. Tissue Specificity: Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. Similarity: Contains 1 C2HC-type zinc finger. Contains 3 MBT repeats. Contains 1 SAM (sterile alpha motif) domain. SWISS: Q9Y468 Gene ID: 26013 Database links: Entrez Gene: 26013 Human Entrez Gene: 241764 Mouse Omim: 608802 Human SwissProt: Q9Y468 Human SwissProt: A2A5N8 Mouse Unigene: 709356 Human Unigene: 187086 Mouse |
