| 產(chǎn)品編號 | bs-17378R |
| 英文名稱 | Rabbit Anti-4HPPD antibody |
| 中文名稱 | 4-羥基苯丙酮酸氧化酶抗體 |
| 別 名 | HPD; 4 HPPD; 4 hydroxyphenylpyruvate dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; 4HPPD; GLOD3; glyoxalase domain containing 3; HPPDase; PPD. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Dog,GuineaPig,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 45kDa |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human 4HPPD: 161-260/393 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] Function: HPD participates in the tyrosine catabolic pathway by catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate. The mechanism of action of HPD involves a decarboxylation step and an oxidation step, followed by a rearrangement step to form homogentisic acid. Alterations in the structure and activity of HPD are causally related to two different metabolic disorders, the recessively inherited tyrosinemia type III and the dominantly inherited hawkinsinuria. Subcellular Location: Cytoplasmic SWISS: P32754 Gene ID: 3242 Database links: Entrez Gene: 3242 Human Entrez Gene: 15445 Mouse Omim: 609695 Human SwissProt: P32754 Human SwissProt: P49429 Mouse Unigene: 2899 Human Unigene: 439709 Mouse Unigene: 3664 Rat |
