| 產(chǎn)品編號 | bs-17761R |
| 英文名稱 | Rabbit Anti-MRGPRX4 antibody |
| 中文名稱 | MRGPRX4蛋白抗體 |
| 別 名 | G protein coupled receptor MRGX4; G protein coupled receptor SNSR5; G protein coupled receptor SNSR6; GPCR; Mas related G protein coupled receptor member X4; Mas related G protein coupled-receptor family, member X4; MAS related GPR, member X4; Mas-related G-protein coupled receptor member X4; MGC129753; MGC129754; MRGPRX4; MRGX4; MRGX4_HUMAN; Sensory neuron specific G protein coupled receptor 5/6; Sensory neuron-specific G-protein coupled receptor 5/6; SNSR5; SNSR6. |
| 研究領(lǐng)域 | 細(xì)胞生物 G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 36kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MRGPRX4: 251-322/322 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the function of nociceptive neurons. This integral membrane protein may also regulate nociceptor development and/or the sensation or modulation of pain. There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G?q- and G?i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G?q-regulated pathways. G?q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins. Subcellular Location: Cell membrane. Tissue Specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. SWISS: Q96LA9 Gene ID: 117196 Database links: Entrez Gene: 117196 Human Omim: 607230 Human SwissProt: Q96LA9 Human Unigene: 632138 Human |
