| 產(chǎn)品編號 | bs-12811R |
| 英文名稱 | Rabbit Anti-ZNF397 antibody |
| 中文名稱 | 鋅指蛋白387抗體 |
| 別 名 | 2810411K16Rik; MGC13250; Zinc finger and SCAN domain containing protein 15; Zinc finger and SCAN domain-containing protein 15; Zinc finger protein 397; Zinc finger protein 47; ZN397_HUMAN; ZNF 397; ZNF 47; ZNF397; ZNF47; ZSCAN 15; ZSCAN15. |
| 研究領(lǐng)域 | 轉(zhuǎn)錄調(diào)節(jié)因子 鋅指蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 61kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZNF397: 131-230/534 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009] Function: Isoform 3 acts as a DNA-dependent transcriptional repressor. Subcellular Location: Nucleus and Nucleus. Cytoplasm. Tissue Specificity: Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers. Contains 1 SCAN box domain. SWISS: Q8NF99 Gene ID: 84307 Database links: Entrez Gene: 100735295 Guinea pig Entrez Gene: 100052677 Horse Entrez Gene: 84307 Human Entrez Gene: 69256 Mouse Omim: 609601 Human SwissProt: Q8NF99 Human Unigene: 591061 Human |
