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Rabbit Anti-IL-1 Beta  antibody (bs-20448R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-20448R
英文名稱 Rabbit Anti-IL-1 Beta  antibody
中文名稱 白介素1β/IL-1β抗體
別    名 IL1B_HUMAN; Interleukin-1 beta; interleukin 1 beta; IL1F2; IL-1 beta; Catabolin; IL-1; IL1F2; IL1beta; IL1-BETA; IL-1beta; IL-1 Beta; IL-1β; IL1β; IL-1B; IL1B;  
Specific References  (4)     |     bs-20448R has been referenced in 4 publications.
[IF=3.234] Zhang H et al. FcγRI (CD64) contributes to the severity of immune inflammation through regulating NF-κB/NLRP3 inflammasome pathway.Life Sci. 2018 Aug 15;207:296-303.  WB ;  Mouse&Human.  
[IF=3.177] Peng Gao. et al. The role of maternal–foetal interface inflammation mediated by NLRP3 inflammasome in the pathogenesis of recurrent spontaneous abortion. Placenta. 2020 Nov;101:221  WB ;  Human.  
[IF=1.879] Guangdi Li. et al. The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis. Bmc Musculoskel Dis. 2021 Dec;22(1):1-13  WB ;  Human.  
[IF=0] Wu Z et al. GABARAP promotes bone marrow mesenchymal stem cells-based the osteoarthritis cartilage regeneration through the inhibition of PI3K/AKT/mTOR signaling pathway. J Cell Physiol. 2019 Apr 24.  IHC-P ;  Rat.  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse (predicted: Rat,Rabbit,Dog,Bee)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-1 Beta: 151-250/269 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

Function:
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subunit:
Monomer.

Subcellular Location:
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Similarity:
Belongs to the IL-1 family.

SWISS:
P01584

Gene ID:
3553

Database links:

Entrez Gene: 3553 Human

Entrez Gene: 16176 Mouse

Entrez Gene: 24494 Rat

Omim: 147720 Human

SwissProt: P01584 Human

SwissProt: P10749 Mouse

SwissProt: Q63264 Rat

Unigene: 126256 Human

Unigene: 222830 Mouse

Unigene: 9869 Rat



產(chǎn)品圖片
Sample: Blood Cell (Mouse) Lysate at 40 ug Primary: Anti-IL-1 Beta ?(bs-20448R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 31 kD Observed band size: 31 kD
Sample: Jurkat(Human) Cell Lysate at 30 ug Primary: Anti- IL-1 Beta (bs-20448R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kD Observed band size: 31 kD
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