| 產(chǎn)品編號(hào) | bsm-51454M |
| 英文名稱(chēng) | Mouse Anti-KMT5A antibody |
| 中文名稱(chēng) | KMT5A單克隆抗體 |
| 別 名 | KMT5A_HUMAN; N-lysine methyltransferase KMT5A; H4-K20-HMTase KMT5A; AltName: Full=Histone-lysine N-methyltransferase KMT5A; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; PR/SET domain-containing protein 07; PR-Set7; PR/SET07; SET domain-containing protein 8. |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號(hào) | G1F8 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant GST fusion protein encoding N-terminal of human SET07. |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Subcellular Location: Nucleus. Chromosome. Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. Similarity: Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. Contains 1 SET domain. SWISS: Q9NQR1 Gene ID: 387893 Database links: Entrez Gene: 387893 Human Entrez Gene: 67956 Mouse Omim: 607240 Human SwissProt: Q9NQR1 Human SwissProt: Q2YDW7 Mouse Unigene: 443735 Human Unigene: 572262 Human Unigene: 137966 Mouse Unigene: 8879 Rat |
| 產(chǎn)品圖片 |
Sample:
Lane 1: 293 (Human) Cell Lysate
Primary:
Anti-KMT5A (bsm-51454M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 43 kD
Observed band size: 50 kD
|
