| 產(chǎn)品編號 | bsm-51744M |
| 英文名稱 | Mouse Anti-BHLHE41 antibody |
| 中文名稱 | BHLHE41單克隆抗體 |
| 別 名 | SHARP-1; bHLH protein DEC2; bHLHB3; bHLHe41; Class B basic helix loop helix protein 3; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-SHARP-1; BHLHE41; BHLHB3; DEC2; SHARP1; Basic helix-loop-helix domain containing class B3; bHLH protein DEC2; helix protein 41; Class B basic helix loop helix protein 3; Class B basic helix-loop-helix protein 3; Class E basic helix-loop-helix protein 41; DEC2; Differentially expressed in chondrocytes protein 2; Enhancer of split and hairy related protein 1; Enhancer-of-split and hairy-related protein 1; hDEC2; Moderately similar to basic-helix loop helix protein M.musculus; BHE41_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 染色質(zhì)和核信號 神經(jīng)生物學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | F2D12 |
| 交叉反應(yīng) | Human,Mouse,Rat,Chinese Hamster |
| 產(chǎn)品應(yīng)用 | WB=1:1000-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human BHLH3. |
| 亞 型 | IgG2b,κ |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
DEC1 is a 412 amino acid, basic helix-loop-helix (bHLH) containing protein that is involved in the control of proliferation and/or differentiation of several cell types including nerve cells, fibroblasts and chondrocytes. The bHLH region of DEC1 is structurally similar to the bHLH regions of the mammalian HES family, Drosophila hairy and Drosophila Enhancer of split m7. DEC1 is a novel direct target for cAMP in a wide range of cells, and is involved in the control of gene expression in cAMP-activated cells. DEC2, also known as SHARP1, is highly expressed in skeletal muscle and brain. The gene encoding human DEC2 maps to chromosome 12p11.23-p12.1. DEC1 and DEC2 play a role in regulating the mammalian molecular clock by suppressing the transcription of specific clock genes. Both DEC1 and DEC2 are detected in the suprachiasmimc nucleus in a circadian fashion. Brief light impulses induce the expression of DEC1 in a phase-dependent manner. Function: May be a transcriptional repressor that represses both basal and activated transcription. Subunit: Homodimerize. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. SWISS: Q9C0J9 Gene ID: 79365 Database links: Entrez Gene: 79365 Human Entrez Gene: 79362 Mouse SwissProt: Q9C0J9 Human SwissProt: Q99PV5 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lane 1: HeLa cell lysates
Lane 2: RD cell lysates
Lane 3: SH-SY5Y cell lysates
Lane 4: HepG2 cell lysates
Lane 5: Mouse brain tissue lysates
Lane 6: Mouse skeletal muscle tissue lysates
Lane 7: Rat skeletal muscle tissue lysates
Lane 8: Rat brain tissue lysates
Lane 9: CHO cell lysates
Primary: Anti-BHLHE41 (bsm-51744M) at 1/4000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
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