| 產(chǎn)品編號 | bsm-60219R |
| 英文名稱 | Keratin 4 Recombinant Rabbit mAb |
| 中文名稱 | 細(xì)胞角蛋白4重組兔單抗 |
| 別 名 | CK 4; CK4; CYK 4; CK-4; CYK4; Cytokeratin4; Cytokeratin-4; FLJ31692; K4; Keratin 4; Keratin-4; Keratin type II cytoskeletal 4; Keratin4; KRT 4; KRT4; K2C4_HUMAN; Keratin, type II cytoskeletal 4; K4; Type-II keratin Kb4. |
| 研究領(lǐng)域 | 腫瘤 信號轉(zhuǎn)導(dǎo) 上皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | C2H9 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-1:500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 57 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Keratin 4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] Subunit: Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13. Tissue Specificity: Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. DISEASE: Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. Similarity: Belongs to the intermediate filament family. SWISS: P19013 Gene ID: 3851 Database links: Entrez Gene: 3851 Human Omim: 123940 Human SwissProt: P19013 Human Unigene: 654610 Human Unigene: 706527 Human 結(jié)構(gòu)蛋白（Structural Proteins） 細(xì)胞角蛋白是一類與結(jié)構(gòu)相關(guān)的蛋白家族，他們在上皮細(xì)胞中形成了細(xì)胞骨架中間絲。角蛋白在上皮細(xì)胞中往往成對存在，具有組織和細(xì)胞特異性。存在于口腔黏膜、鼻腔、食道和肛門生殖器上皮中的特異角蛋白為CK4和CK13。CK4是II型角蛋白，普遍存在于非角質(zhì)化的鱗狀上皮細(xì)胞中，CK4表達(dá)于基底細(xì)胞，也表達(dá)于鱗狀細(xì)胞癌。 |
| 產(chǎn)品圖片 |
Tissue: Human tonsil
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:5000
Primary ab incubation condition: 1 hour at room
Tissue: Human esophagus
Section type: Formalin fixed & Paraffin -embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary ab dilution: 1:5000
Primary ab incubation condition: 1 hour at r
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