| 產(chǎn)品編號(hào) | bsm-60265M |
| 英文名稱(chēng) | Mouse Anti-HDAC3 antibody |
| 中文名稱(chēng) | 組蛋白去乙?；?單克隆抗體 |
| 別 名 | HDAC3_HUMAN; Histone deacetylase 3; EC:3.5.1.98; HD3; Protein deacetylase HDAC3; EC:3.5.1.; Protein deacylase HDAC3; RPD3-2; SMAP45; SMAP 45; SMAP-45; RPD3; KDAC3; |
| 抗體來(lái)源 | Mouse |
| 克隆類(lèi)型 | Monoclonal |
| 克 隆 號(hào) | C12C4 |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 47kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 亞 型 | IgG2a/Kappa |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | 負(fù)責(zé)核心組蛋白（H2A、H2B、H3和H4）N端部分和其他一些非組蛋白底物上賴(lài)氨酸殘基的脫乙酰。組蛋白去乙酰化為表觀遺傳抑制提供了一個(gè)標(biāo)簽，在轉(zhuǎn)錄調(diào)控、細(xì)胞周期進(jìn)展和發(fā)育事件中起著重要作用。組蛋白脫乙?；竿ㄟ^(guò)形成大的多蛋白復(fù)合物起作用。通過(guò)使增強(qiáng)子元件上的H3'Lys-27'（H3K27）去乙?；?，拮抗EP300乙酰轉(zhuǎn)移酶活性和抑制近端基因表達(dá)，參與BCL6轉(zhuǎn)錄抑制因子的活性 |
| 產(chǎn)品圖片 |
Blocking buffer: 5% NFDM/TBST
Primary ab dilution: 1:1000
Primary ab incubation condition: 2 hours at room temperature
Lysate: HeLa, HepG2, Neuro-2a, EL4.IL-2, BRL
Protein loading quantity: 20 μg
Exposure time: 10 s
Predicted MW: 48 kDa
Observed MW: 48 kDa
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