| 產(chǎn)品編號(hào) | V5706 |
| 英文名稱 | Alpha-synuclein |
| 中文名稱 | 核突觸蛋白-α單克隆抗體 |
| 別 名 | SNCA; SYUA_HUMAN; Alpha synuclein; Alpha-synuclein, isoform NACP140; alpha SYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid precursor; Non-A-beta component of alzheimers disease amyloid , precursor of; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease (autosomal dominant, Lewy body) 4; Parkinson disease familial 1; Syn; Snca synuclein, alpha (non A4 component of amyloid precursor); Synuclein alpha; Synuclein, alpha (non A4 component of amyloid precursor); Synuclein-α; Synuclein α. |
| 理論分子量 | 14kDa |
| 性 狀 | Liquid |
| 緩 沖 液 | 0.01M PBS(pH7.4). |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]. Synuclein 包括α-Synuclein，β-Synuclein 和γ-Synuclein 是神經(jīng)細(xì)胞中富含的前突觸蛋白。α-Synuclein，Alzheimer’(AD)病淀粉樣蛋白沉積的成份之一，集中分布在神經(jīng)細(xì)胞的包體和突觸。在帕金森病人中發(fā)現(xiàn)有α-Synuclein的變異型，而γ-Synuclein與軸突病理學(xué)有關(guān)。 此抗體將為Lewy小體癡呆癥、Parkinson癥、AD和其它一些神經(jīng)性疾病提供有用的病理診斷。 |
