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    Rabbit Anti-ABCB5/BF488 Conjugated antibody (bs-1604R-BF488)
    訂購熱線:400-901-9800
    訂購郵箱:sales@www.p2b3.cn
    訂購QQ:  400-901-9800
    技術(shù)支持:techsupport@www.p2b3.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產(chǎn)品編號 bs-1604R-BF488
    英文名稱1 Rabbit Anti-ABCB5/BF488 Conjugated antibody
    中文名稱 BF488標記的ATP結(jié)合蛋白家族5抗體
    別    名 ATP-binding cassette sub-family B member 5; ABCB 5; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; EST422562; P glycoprotein ABCB5; ABCB5_HUMAN.  
    規(guī)格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領(lǐng)域 腫瘤  信號轉(zhuǎn)導  通道蛋白  糖蛋白  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, )
    產(chǎn)品應用 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 89/138kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human ABCB5
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產(chǎn)品介紹 background:
    ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

    Function:
    Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.

    Subcellular Location:
    Cell membrane; Multi-pass membrane protein.

    Tissue Specificity:
    Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.

    Similarity:
    Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 2 ABC transporter domains.

    Database links:

    Entrez Gene: 340273 Human

    Omim: 611785 Human

    SwissProt: Q2M3G0 Human

    Unigene: 404102 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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