| 產(chǎn)品編號 | bs-1635R-Gold |
| 英文名稱1 | Rabbit Anti-CD57/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的髓鞘相關(guān)糖蛋白CD57抗體 |
| 別 名 | 3-glucuronyltransferase 1; 3-glucuronyltransferase; B3GA1_HUMAN; B3GAT1; Beta 1 3 glucuronyltransferase 1; Beta-1; CD 57; CD57; CD57 antigen; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; GlcAT P; GlcAT-P; GLCATP; GlcUAT P; GlcUAT-P; GlcUATP; Glucuronosyltransferase P; HNK 1; HNK1; LEU 7; LEU7; LEU7 antigen; NK 1; NK1; UDP GlcUA glycoprotein beta 1 3 glucuronyltransferase; UDP-GlcUA:glycoprotein beta-1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD57 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: CD57 recognizes a (Mr 100-110kDa) oligosaccharide antigenic determinant on myeloid cells and on a variety of polypeptides, lipids and chondroitan sulfate proteoglycans. This surface antigen is associated with myelin-associated glycoprotein (MAG). The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system. Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Subunit: Homodimer (Potential). Subcellular Location: Golgi apparatus membrane; Single-pass type II membrane protein. Tissue Specificity: Mainly expressed in the brain. Similarity: Belongs to the glycosyltransferase 43 family. Database links: Entrez Gene: 27087 Human Omim: 151290 Human SwissProt: Q9P2W7 Human Unigene: 381050 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD57是一種分子量為110KD的糖蛋白,它是自然殺傷細(xì)胞(NK)和殺傷細(xì)胞的特異性表面抗原。CD57表達(dá)于15-20%的外周血單核細(xì)胞，60%的NK活化細(xì)胞以及T細(xì)胞亞群。該抗體可以標(biāo)記NK細(xì)胞，也可識別非淋巴組織的一些細(xì)胞。可用于NK細(xì)胞介導(dǎo)的細(xì)胞毒、NK細(xì)胞及T細(xì)胞亞群的功能等方面的研究，也可標(biāo)記神經(jīng)內(nèi)分泌細(xì)胞及其腫瘤。 |
