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Rabbit Anti-SPON2/RBITC Conjugated antibody (bs-11064R-RBITC)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
技術(shù)支持:techsupport@www.p2b3.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11064R-RBITC
英文名稱1 Rabbit Anti-SPON2/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的細胞外基質(zhì)底物反應(yīng)蛋白2抗體
別    名 M spondin; Mindin; SPON 2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL 1; DIL-1; DIL1; M spondin; Mindin; Spon2; SPON2_HUMAN; Spondin 2; Spondin-2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學  信號轉(zhuǎn)導(dǎo)  細胞粘附分子  細胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPON2_HUMAN
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous and non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin and Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus and a Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions.

Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Subunit:
Monomer. Interacts with integrin.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tissue Specificity:
Expressed in normal lung tissue but not in lung carcinoma cell lines.

Similarity:
Contains 1 spondin domain. Contains 1 TSP type-1 domain.

Database links:

Entrez Gene: 10417 Human

Entrez Gene: 100689 Mouse

Entrez Gene: 171569 Rat

Omim: 605918 Human

SwissProt: Q9BUD6 Human

SwissProt: Q8BMS2 Mouse

SwissProt: Q9WV75 Rat

Unigene: 302963 Human

Unigene: 635350 Human

Unigene: 34694 Mouse

Unigene: 6699 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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