| 產(chǎn)品編號(hào) |
bs-10073R-Cy5.5 |
| 英文名稱1 |
Rabbit Anti-PDGF-A/Cy5.5 Conjugated antibody
|
| 中文名稱 |
Cy5.5標(biāo)記的血小板源性生長(zhǎng)因子A抗體 |
| 別 名 |
Platelet–dirived growth factor–1; PDGFA; PDGF AA; PDGF-AA; PDGF A chain; PDGF subunit A; PDGF-1; PDGF1; PDGFA; PDGFA_HUMAN; Platelet derived growth factor A chain precursor; Platelet derived growth factor alpha polypeptide; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 研究領(lǐng)域 |
腫瘤 免疫學(xué) 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類(lèi)型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Mouse,
(predicted: Rat, Rabbit, )
|
| 產(chǎn)品應(yīng)用 |
Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
14kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human PDGF-A |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heal the wound. Antiparallel disulfide-linked dimer of nonidentical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. The long form contains a basic insert which acts as a cell retention signal. A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor. It belongs to the PDGF/VEGF growth factor family.
Function:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.
Subunit:
Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFB; antiparallel disulfide-linked dimer. The PDGFA homodimer interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with CSPG4.
Subcellular Location:
Secreted. Note=Released by platelets upon wounding.
Tissue Specificity:
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:
Entrez Gene: 5154 Human
Entrez Gene: 5155 Human
Entrez Gene: 18590 Mouse
Entrez Gene: 18591 Mouse
Entrez Gene: 24628 Rat
Entrez Gene: 25266 Rat
Omim: 173430 Human
Omim: 190040 Human
SwissProt: P01127 Human
SwissProt: P04085 Human
SwissProt: P20033 Mouse
SwissProt: P31240 Mouse
SwissProt: P28576 Rat
SwissProt: Q05028 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PDGF-A（platelet-dirived growth factor-A）是一種堿性蛋白，pdgf促進(jìn)細(xì)胞分裂、增值同時(shí)，可誘導(dǎo)c-fos、c-myc等蛋白表達(dá)增強(qiáng)。
主要作用：參與組織和血管修復(fù)、促進(jìn)平滑肌細(xì)胞、成纖維細(xì)胞迅速增值。分子量為28-35kDa，分為兩個(gè)亞基（A、B鏈）通過(guò)二硫鍵結(jié)合而成的兩條多肽鏈的異二聚體。最新研究發(fā)現(xiàn)了PDGF家族兩種新的基因PDGF-C、PDGF-D。
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