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Rabbit Anti-CD56/Biotin Conjugated antibody (bs-0736R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0736R-Bio
英文名稱1 Rabbit Anti-CD56/Biotin Conjugated antibody
中文名稱 生物素標記的神經(jīng)細胞粘附分子1抗體
別    名 CD56 antigen; Cell Adhesion Molecule Neural 1; MSK39; N CAM 120; N CAM 140; N CAM 180; NCAM 1; NCAM 120; NCAM 140; NCAM1; Neural cell adhesion molecule 1 120 kDa isoform; Neural cell adhesion molecule 1 140 kDa isoform; Neural cell adhesion molecule 1; NCAM1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經(jīng)生物學  干細胞  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD56/NCAM1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Function:
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

Subcellular Location:
Isoform 1, 2,: Cell membrane; Single-pass type I membrane protein. Isoform 3, 4: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 5, 6: Secreted.

Similarity:
Contains 2 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Database links:

Entrez Gene: 4684 Human

Entrez Gene: 17967 Mouse

Entrez Gene: 24586 Rat

Omim: 116930 Human

SwissProt: P13591 Human

SwissProt: P13595 Mouse

SwissProt: P13596 Rat

Unigene: 503878 Human

Unigene: 711235 Human

Unigene: 733031 Human

Unigene: 439182 Mouse

Unigene: 4974 Mouse

Unigene: 11283 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細胞粘附蛋白(Call Adhesion Protein)
神經(jīng)元標志物

NCAM-1為神經(jīng)細胞粘附分子,主要分布于神經(jīng)組織,神經(jīng)—肌肉接頭,神經(jīng)—內(nèi)分泌腺和某些內(nèi)分泌腺以及大多數(shù)神經(jīng)外胚層來源的細胞、組織和腫瘤中。
NCAM 1主要用于視網(wǎng)膜母細胞瘤、髓母細胞瘤、星形細胞瘤、神經(jīng)母細胞瘤等腫瘤方面的研究。CD56(神經(jīng)細胞黏附分子,NCAM)表達于大部分神經(jīng)外胚層來源的細胞系、組織和腫瘤如視網(wǎng)膜母細胞瘤、成神經(jīng)管細胞瘤、星形細胞瘤以及成神經(jīng)細胞瘤。它也表達于一些中胚層來源的腫瘤如橫紋肌肉瘤。NK細胞以及NK細胞淋巴瘤為陽性。CD56被認為是NK細胞腫瘤的重要標志物。該抗體識別分子量為180,145和125kDa亞型。
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