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Rabbit Anti-CD56/RBITC Conjugated antibody (bs-0736R-RBITC)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0736R-RBITC
英文名稱(chēng)1 Rabbit Anti-CD56/RBITC Conjugated antibody
中文名稱(chēng) 羅丹明(RBITC)標(biāo)記的神經(jīng)細(xì)胞粘附分子1抗體
別    名 CD56 antigen; Cell Adhesion Molecule Neural 1; MSK39; N CAM 120; N CAM 140; N CAM 180; NCAM 1; NCAM 120; NCAM 140; NCAM1; Neural cell adhesion molecule 1 120 kDa isoform; Neural cell adhesion molecule 1 140 kDa isoform; Neural cell adhesion molecule 1; NCAM1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  干細(xì)胞  細(xì)胞類(lèi)型標(biāo)志物  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD56/NCAM1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

Function:
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

Subcellular Location:
Isoform 1, 2,: Cell membrane; Single-pass type I membrane protein. Isoform 3, 4: Cell membrane; Lipid-anchor, GPI-anchor. Isoform 5, 6: Secreted.

Similarity:
Contains 2 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Database links:

Entrez Gene: 4684 Human

Entrez Gene: 17967 Mouse

Entrez Gene: 24586 Rat

Omim: 116930 Human

SwissProt: P13591 Human

SwissProt: P13595 Mouse

SwissProt: P13596 Rat

Unigene: 503878 Human

Unigene: 711235 Human

Unigene: 733031 Human

Unigene: 439182 Mouse

Unigene: 4974 Mouse

Unigene: 11283 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細(xì)胞粘附蛋白(Call Adhesion Protein)
神經(jīng)元標(biāo)志物

NCAM-1為神經(jīng)細(xì)胞粘附分子,主要分布于神經(jīng)組織,神經(jīng)—肌肉接頭,神經(jīng)—內(nèi)分泌腺和某些內(nèi)分泌腺以及大多數(shù)神經(jīng)外胚層來(lái)源的細(xì)胞、組織和腫瘤中。
NCAM 1主要用于視網(wǎng)膜母細(xì)胞瘤、髓母細(xì)胞瘤、星形細(xì)胞瘤、神經(jīng)母細(xì)胞瘤等腫瘤方面的研究。CD56(神經(jīng)細(xì)胞黏附分子,NCAM)表達(dá)于大部分神經(jīng)外胚層來(lái)源的細(xì)胞系、組織和腫瘤如視網(wǎng)膜母細(xì)胞瘤、成神經(jīng)管細(xì)胞瘤、星形細(xì)胞瘤以及成神經(jīng)細(xì)胞瘤。它也表達(dá)于一些中胚層來(lái)源的腫瘤如橫紋肌肉瘤。NK細(xì)胞以及NK細(xì)胞淋巴瘤為陽(yáng)性。CD56被認(rèn)為是NK細(xì)胞腫瘤的重要標(biāo)志物。該抗體識(shí)別分子量為180,145和125kDa亞型。
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