| 產品編號 | bs-0155R-AP |
| 英文名稱1 | Rabbit Anti-CRP/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標記的C-反應蛋白抗體 |
| 別 名 | C-reactive protein; C Reactive Protein; C reactive protein pentraxin related; CRP; MGC88244; PTX 1; PTX1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領域 | 心血管 免疫學 信號轉導 細胞凋亡 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, ) |
| 產品應用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRP (151-200aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產品介紹 |
background: Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers. Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular Location: Secreted. Tissue Specificity: Found in plasma. Similarity: Belongs to the pentaxin family. Contains 1 pentaxin domain. Database links: Entrez Gene: 1401 Human Omim: 123260 Human SwissProt: P02741 Human Unigene: 76452 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. C反應蛋白 CRP（C-reactive protin）是與C性肺炎球菌的多糖起反應的一種蛋白，在某些細菌的感染過程中出現(xiàn)在血漿中。 CRP是在一些病理性情況下出現(xiàn)于病人血清中的一種糖蛋白，特別是在伴有肯炎癥和組織壞死疾病的急性期。血清中出現(xiàn)的這種異常蛋白能和肺炎C-多糖體發(fā)生沉淀反應，當疾病好轉或緩解時，CRP減低或消失。 臨床意義: (1)各種急性化膿性炎癥、菌血癥、組織壞死(心肌梗塞、手術、嚴重創(chuàng)傷、燒傷等)、惡性腫瘤、結締組織病、腎移殖后急性排異反應、急性風濕熱、風濕性關節(jié)炎、類風濕性關節(jié)炎、心肌炎急性期、肺炎、肺結核、系統(tǒng)性紅斑狼瘡、急性肝炎和闌尾炎等，血清中CRP含量可增高，它的出現(xiàn)比其它急性期的反應物質早，所以對疾病的早期診斷很有幫助。 CRP可以鑒別細菌炎癥或者是病毒性炎癥。細菌性炎癥CRP可以明顯增高，而病毒性炎癥CRP的血清含量一般都在正常范圍。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
