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Rabbit Anti-Phospho-GCN2 (Thr899)/RBITC Conjugated antibody (bs-3155R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3155R-RBITC
英文名稱1 Rabbit Anti-Phospho-GCN2 (Thr899)/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的磷酸化蛋白激酶GCN2蛋白抗體
別    名 GCN2 (phospho T899); p-GCN2 (phospho T899); EIF2AK4; Eukaryotic Translation Initiation Factor 2-alpha kinase 4; GCN2-like protein; KIAA1338; E2AK4_HUMAN; Eif2ak4; Eukaryotic Translation Initiation Factor 2 alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; MGCN2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  染色質和核信號  神經生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 189kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human GCN2 around the phosphorylation site of Thr899
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.

Function:
Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Autophosphorylated on threonine residues.

Similarity:
Belongs to the protein kinase superfamily.
Ser/Thr protein kinase family. GCN2 subfamily.
Contains 2 protein kinase domains.
Contains 1 RWD domain.

Database links:

Entrez Gene: 440275 Human

Entrez Gene: 27103 Mouse

Entrez Gene: 114859 Rat

Omim: 609280 Human

SwissProt: Q9P2K8 Human

SwissProt: Q9QZ05 Mouse

Unigene: 656673 Human

Unigene: 217616 Mouse

Unigene: 8333 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GCN2蛋白的作用;可能是將短期記憶變成長期記憶的一個主控調節(jié)因子, GCN2蛋白在長期記憶形成中功能的發(fā)現將可能幫助研究人員開發(fā)出提高記憶力喪失的病人提高記憶力。
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