| 產(chǎn)品編號(hào) | bs-1188R-AP |
| 英文名稱1 | Rabbit Anti-FRA2/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的FRA2/FOSL2抗體 |
| 別 名 | FLJ23306; Fos L2; FOS like antigen 2; Fos related antigen 2; FosL 2; FosL2; FOSL2; FOSL2_HUMAN; FRA 2; fos-related antigen 2. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FRA2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Fos and Jun dimerize to form Activator Protein 1 (AP1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13 acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP1 dependent genes. Function: Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). Subunit: Heterodimer Subcellular Location: Nuclear Similarity: Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain. Database links: Entrez Gene: 2355 Human Entrez Gene: 421416 Chicken Entrez Gene: 14284 Mouse Omim: 601575 Human SwissProt: P18625 Chicken SwissProt: P15408 Human SwissProt: P47930 Mouse Unigene: 220971 Human Unigene: 596972 Human Unigene: 24684 Mouse Unigene: 10962 Rat Unigene: 163577 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FOSL2蛋白對(duì)細(xì)胞因子、生長(zhǎng)因子、感染或致癌刺激等生理或病理信號(hào)發(fā)生應(yīng)答,調(diào)節(jié)基因的轉(zhuǎn)錄, 參與細(xì)胞的增殖、分化等過(guò)程. FOSL2在腫瘤形成及發(fā)展過(guò)程中, 通過(guò)促進(jìn)細(xì)胞增殖、抑制分化、促進(jìn)腫瘤細(xì)胞的侵襲和轉(zhuǎn)移等過(guò)程發(fā)揮作用. |
