| 產(chǎn)品編號 | bs-0560R-BF488 |
| 英文名稱1 | Rabbit Anti-IL-13/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的白介素13抗體 |
| 別 名 | ALRH; BHR 1; BHR1; IL 13; IL13; Interleukin 13; Interleukin13; MGC116786; MGC116788; MGC116789; NC30; P600; IL13_MOUSE; Interleukin-13; IL-13; T-cell activation protein P600. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-13 (45-56aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Human IL13 was originally identified by differential screening of an anti CD28 activated human peripheral blood mononuclear cell cDNA library as an induction specific novel cytokine. It was also isolated from cDNA libraries of human T cell clones using the murine IL13 (P600) cDNA as a probe. Human IL13, a pleiotropic cytokine, is produced by activated Th0, Th1 like, Th2 like, and CD8 T cells. The gene for human IL13 maps to chromosome 5 and is closely linked to the genes for IL3, IL4, IL5, and GMCSF. IL13 inhibits proinflammatory cytokine production and stimulates antibody production. It induces proliferation in the human pre myeloid cell line TF1. IL13 has multiple effects on the differentiation and functions of monocytes and macrophages. It suppresses cytotoxic functions and induces changes in the morphology of human monocytes and in the phenotype of human monocytes and B cells by upregulating MHC class II expression. IL13 will also decrease the production of nitric oxide by activated murine macrophages, leading to impaired parasiticidal activity. Human and mouse interleukin 13 share approximately 58% amino acid sequence identity. Although human and mouse IL13 are equally active on human cells, human IL13 is much less active than mouse IL13 on mouse cells. Human IL13 and human IL4 also share approximately 30% sequence homology and have similar biological functions. Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Subcellular Location: Secreted. DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Similarity: Belongs to the IL-4/IL-13 family. Database links: Entrez Gene: 3596 Human Entrez Gene: 16163 Mouse Omim: 147683 Human SwissProt: P35225 Human SwissProt: P20109 Mouse Unigene: 845 Human Unigene: 1284 Mouse Unigene: 9921 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生長因子和激素（ Growth Factor and Hormones） IL-13是由Ｔ細(xì)胞、嗜堿粒細(xì)胞、漿細(xì)胞及樹突狀細(xì)胞產(chǎn)生的細(xì)胞因子。 IL-13誘導(dǎo)、維持一定IgE水平，增強(qiáng)巨噬細(xì)胞及樹突狀細(xì)胞活性，活化嗜酸粒細(xì)胞并防止其凋亡，廣泛參與過敏性及炎性疾病過程。 |
