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Rabbit Anti-APRIN/RBITC Conjugated antibody (bs-7722R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7722R-RBITC
英文名稱1 Rabbit Anti-APRIN/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的雄激素誘導增殖抑制蛋白抗體
別    名 Androgen induced proliferation inhibitor; Androgen induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff associated protein AS3; APRIN; AS3; CG008; PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); Sister chromatid cohesion protein PDS5 homolog B; AW212954; mKIAA0979; RP1 267P19.1; AI646570.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 165kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APRIN/PDS5B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010].

Function:
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

Subunit:
Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable).

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the PDS5 family.
Contains 3 A.T hook DNA-binding domains.
Contains 1 HEAT repeat.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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