| 產(chǎn)品編號(hào) | bs-0413R-BF350 |
| 英文名稱1 | Rabbit Anti-MMP-3/BF350 Conjugated antibody |
| 中文名稱 | BF350標(biāo)記的基質(zhì)金屬蛋白酶3抗體 |
| 別 名 | matrix metalloproteinase-3; Transin-1; SL-1; SL 1; SL1; Stromelysin-1 precursor; MMP3 Stromelysin-1; EMS-2; Matrix metalloproteinase 3; Matrix metalloproteinase-3; Matrix metalloproteinase 3 preproprotein; MGC126102; MGC126103; MGC126104; MMP 3; MMP3; Progelatinase; Proteoglycanase;STMY; STMY1; STR1; Stromelisin 1; Stromelysin 1 progelatinase; Transin 1; MMP3_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Horse, Sheep, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42/52kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MMP3 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Function: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. Database links: Entrez Gene: 4314 Human Entrez Gene: 17392 Mouse Omim: 185250 Human SwissProt: P08254 Human SwissProt: P28862 Mouse Unigene: 375129 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） 基質(zhì)金屬蛋白酶(matrix metalloproteinases, MMPs)是一族依賴鋅離子而降解各種細(xì)胞外基質(zhì)的蛋白酶，亦稱IV型膠原酶或稱明膠酶A，其主要功能為降解IV型膠原，因而它在腫瘤細(xì)胞突破基底膜屏障和浸潤轉(zhuǎn)移中起重要作用。 |
