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Rabbit Anti-phospho-gamma Adducin (Ser693)/BF647 Conjugated antibody (bs-10223R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10223R-BF647
英文名稱1 Rabbit Anti-phospho-gamma Adducin (Ser693)/BF647 Conjugated antibody
中文名稱 BF647標記的磷酸化內(nèi)收蛋白gamma抗體
別    名 ADD3; ADDG_HUMAN; ADDL; Adducin 3 (gamma); Adducin 3; Adducin-like protein 70; Gamma-adducin.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human gamma Adducin around the phosphorylation site of Ser693
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subunit:
Heterodimer of an alpha and a gamma subunit.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Isoform 1 is ubiquitously expressed.

Post-translational modifications:
Sumoylated.

Similarity:
Belongs to the aldolase class II family. Adducin subfamily.

Database links:

Entrez Gene: 120 Human

Entrez Gene: 27360 Mouse

Entrez Gene: 25230 Rat

Omim: 601568 Human

SwissProt: Q9UEY8 Human

SwissProt: Q9QYB5 Mouse

SwissProt: Q62847 Rat

Unigene: 501012 Human

Unigene: 426080 Mouse

Unigene: 76589 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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