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Rabbit Anti-Ribonuclease 3/ECP/Gold Conjugated antibody (bs-8615R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-8615R-Gold
英文名稱1 Rabbit Anti-Ribonuclease 3/ECP/Gold Conjugated antibody
中文名稱 膠體金標記的嗜酸性粒細胞陽離子蛋白抗體
別    名 eosinophil cationic protein; EAR; Ear11; Ear4; EAR5; ECP; LOC192264; MGC143624; mR3; mR5; R1; R14; R15; R17; R5; R7; Ribonuclease 3; Rnase17; Rnase2; RNASE3; RNS3; ECP_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ribonuclease 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
ECP is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis, and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases

Function:
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.

Subcellular Location:
Cytoplasmic granule. Matrix of eosinophil's large specific granule.

Similarity:
Belongs to the pancreatic ribonuclease family.

Database links:

Entrez Gene: 6037 Human

Entrez Gene: 53876 Mouse

Entrez Gene: 100361866 Rat

Entrez Gene: 192264 Rat

Omim: 131398 Human

SwissProt: P12724 Human

SwissProt: O35290 Mouse

SwissProt: P70709 Rat

Unigene: 73839 Human

Unigene: 327386 Mouse

Unigene: 10626 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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