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Rabbit Anti-TXNDC4/Cy7 Conjugated antibody (bs-10507R-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10507R-Cy7
英文名稱1 Rabbit Anti-TXNDC4/Cy7 Conjugated antibody
中文名稱 Cy7標記的內質網(wǎng)蛋白44抗體
別    名 Endoplasmic reticulum resident protein 44; Endoplasmic reticulum resident protein 44 kDa; Endoplasmic reticulum resident protein ERp44; ER protein 44; ERP44; KIAA0573; PDIA10; Protein disulfide isomerase family A, member 10; Thioredoxin domain containing 4 (endoplasmic reticulum); Thioredoxin domain containing protein 4; UNQ532/PRO1075; ERP44; ERP44_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  染色質和核信號  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TXNDC4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.

Function:
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.

Subunit:
Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration.

Subcellular Location:
Endoplasmic reticulum lumen.

Similarity:
Contains 1 thioredoxin domain.

Database links:

Entrez Gene: 23071 Human

Entrez Gene: 506157 Cow

Entrez Gene: 474781 Dog

Entrez Gene: 100414815 Marmoset (common)

Entrez Gene: 76299 Mouse

Entrez Gene: 100192437 Pig

Entrez Gene: 298066 Rat

Omim: 609170 Human

SwissProt: Q3T0L2 Cow

SwissProt: Q9BS26 Human

SwissProt: Q9D1Q6 Mouse

Unigene: 154023 Human

Unigene: 317701 Mouse

Unigene: 2459 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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