| 產(chǎn)品編號(hào) | bs-17170R-BF594 |
| 英文名稱1 | Rabbit Anti-TPMT/BF594 Conjugated antibody |
| 中文名稱 | BF594標(biāo)記的硫嘌呤甲基轉(zhuǎn)移酶抗體 |
| 別 名 | HGNC:12014; S adenosyl L methionine thiopurine S methyltransferase; Thiopurine methyltransferase; Thiopurine S methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMT_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 新陳代謝 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TPMT |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Subcellular Location: Cytoplasm. DISEASE: Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460]. TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. Similarity: Belongs to the methyltransferase superfamily. TPMT family. Database links: Entrez Gene: 7172 Human Entrez Gene: 22017 Mouse Omim: 187680 Human SwissProt: P51580 Human SwissProt: O55060 Mouse Unigene: 444319 Human Unigene: 10169 Mouse Unigene: 112598 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TPMT是硫嘌呤類藥物（如硫唑嘌呤、巰嘌呤和硫鳥嘌呤）的代謝中最主要的酶之一，起到的作用是在這類化合物的硫原子上增加一個(gè)甲基；這個(gè)過(guò)程中提供甲基的是S-腺苷甲硫氨酸，后者同時(shí)被轉(zhuǎn)化成S-腺苷-L-高半胱氨酸。 TPMT基因的缺陷會(huì)讓人體無(wú)法將這類藥物滅活，未代謝的藥物因此在體內(nèi)大量累積，從而引起嚴(yán)重甚至致命的骨髓抑制，表現(xiàn)為貧血、血小板減少癥（導(dǎo)致出血）和白細(xì)胞減少癥（導(dǎo)致感染）等. |
