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Rabbit Anti-SHMT2/BF488 Conjugated antibody (bs-17469R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17469R-BF488
英文名稱 Rabbit Anti-SHMT2/BF488 Conjugated antibody
中文名稱 BF488標記的絲氨酸甲基化酶mSHMT抗體
別    名 GLY A+; GLYA; glycine auxotroph A, human complement for hamster; Glycine hydroxymethyltransferase; GLYM_HUMAN; mitochondrial; Serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase; Serine hydroxymethyltransferase mitochondrial; Serine methylase; SHMT 2; SHMT; SHMT2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHMT2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.

Subcellular Location:
Mitochondrion. Mitochondrion matrix > mitochondrion nucleoid. Mitochondrion inner membrane.

Similarity:
Belongs to the SHMT family.

Database links:

Entrez Gene: 6472 Human

Entrez Gene: 108037 Mouse

Entrez Gene: 299857 Rat

Omim: 138450 Human

SwissProt: P34897 Human

Unigene: 741179 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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