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Rabbit Anti-MOSC2/Gold Conjugated antibody (bs-17725R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17725R-Gold
英文名稱1 Rabbit Anti-MOSC2/Gold Conjugated antibody
中文名稱 膠體金標記的MOSC2蛋白抗體
別    名 FLJ20605; mitochondrial; MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2; MOSC2; MOSC2_HUMAN; RP11-270A6.1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MOSC2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
MOSC2 is a 335 amino acid peripheral membrane protein that localizes to the mitochondria. Containing a MOSC domain, MOSC2 utilizes molybdenum as a cofactor and is a component of the benzamidoxime prodrug-converting complex that is comprised of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3). CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. Benzamidoxime prodrug-converting complex is required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. MOSC2 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 1q41.

Function:
Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.

Subcellular Location:
Mitochondrion outer membrane.

Similarity:
Contains 1 MOSC domain.

Database links:

Entrez Gene: 54996 Human

Entrez Gene: 67247 Mouse

SwissProt: Q969Z3 Human

SwissProt: Q922Q1 Mouse

Unigene: 369042 Human

Unigene: 177724 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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