| 產(chǎn)品編號(hào) | bs-19160R-FITC |
| 英文名稱1 | Rabbit Anti-ZFYVE28/FITC Conjugated antibody |
| 中文名稱 | FITC標(biāo)記的鋅指蛋白結(jié)構(gòu)域ZFYVE28抗體 |
| 別 名 | hLst2; Lateral signaling target protein 2 homolog; LST2; LST2_HUMAN; LYST2; MGC43699; MGC61592; zfyve28; Zinc finger FYVE domain containing 28; Zinc finger FYVE domain-containing protein 28. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 96kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ZFYVE28 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: ZFYVE28 is an 887 amino acid protein that contains one FYVE-type zinc finger, which mediates the interaction with PI3P (phosphatidylinositol 3-phosphate). ZFYVE28 functions as a negative regulator of EGFR (epidermal growth factor receptor) by promoting its degradation in endosomes when not monoubiquinated on Lys-87. In the absence of monoubiquination, ZFYVE28 localizes to the early endosome membrane, while it localizes to the cytosol when it is monoubiquinated. There are five isoforms of ZFYVE28 that are produced as a result of alternative splicing events. Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated. Subcellular Location: Cytoplasm > cytosol. Early endosome membrane. Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated. Post-translational modifications: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. Similarity: Belongs to the lst-2 family. Contains 1 FYVE-type zinc finger. Database links: Entrez Gene: 57732 Human Entrez Gene: 231125 Mouse Omim: 614176 Human SwissProt: Q9HCC9 Human SwissProt: Q6ZPK7 Mouse Unigene: 292056 Human Unigene: 113388 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
