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Rabbit Anti-TIMM8B/Cy5.5 Conjugated antibody (bs-23056R-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-23056R-Cy5.5
英文名稱1 Rabbit Anti-TIMM8B/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的線粒體內(nèi)膜轉(zhuǎn)位酶8B
別    名 DDP2; Deafness dystonia protein 2; FLJ21744; MGC102866; MGC117373; Mitochondrial import inner membrane translocase subunit Tim8 B; Small zinc finger like protein DDP2; TIM8B; ranslocase of inner mitochondrial membrane 8 homolog B (yeast); Translocase of inner mitochondrial membrane 8 homolog b;   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 9kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMM8B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]

Function:
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).

Subunit:
Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Tissue Specificity:
Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Similarity:
Belongs to the small Tim family.

Database links:

Entrez Gene: 26521 Human

Entrez Gene: 30057 Mouse

Entrez Gene: 64372 Rat

Omim: 606659 Human

SwissProt: Q9Y5J9 Human

SwissProt: P62077 Mouse

SwissProt: P62078 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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