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Rabbit Anti-NSL1/Gold Conjugated antibody (bs-19471R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-19471R-Gold
英文名稱1 Rabbit Anti-NSL1/Gold Conjugated antibody
中文名稱 膠體金標記的著絲粒相關蛋白NSL1抗體
別    名 4833432M17Rik; AI451597; C1orf48; DC31; DC8; DKFZp566O1646; Gm105; Gm984; Kinetochore associated protein NSL1 homolog; Kinetochore-associated protein NSL1 homolog; MIS14; NSL1; NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); NSL1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  染色質和核信號  轉錄調節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 32kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NSL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]

Function:
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Subunit:
Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5.

Subcellular Location:
Nucleus. Chromosome > centromere > kinetochore. Associated with the kinetochore.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Database links:

Entrez Gene: 25936 Human

SwissProt: Q96IY1 Human

Unigene: 497692 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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