| 產(chǎn)品編號(hào) | bs-19853R-BF488 |
| 英文名稱1 | Rabbit Anti-RGS12/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的G蛋白信號(hào)轉(zhuǎn)導(dǎo)調(diào)節(jié)因子12抗體 |
| 別 名 | DKFZp761K1617; Regulator of G protein signalling 12. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 表觀遺傳學(xué) G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 156kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RGS12 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis. Subunit: Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent. Subcellular Location: Nuclear Tissue Specificity: Isoform 3 is brain specific. Similarity: Contains 1 GoLoco domain. Contains 1 PDZ (DHR) domain. Contains 1 PID domain. Contains 2 RBD (Ras-binding) domains. Contains 1 RGS domain. Database links: Entrez Gene: 6002 Human Entrez Gene: 71729 Mouse Omim: 602512 Human SwissProt: O14924 Human SwissProt: Q8CGE9 Mouse Unigene: 196208 Mouse Unigene: 9796 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
