| 產(chǎn)品編號(hào) |
bs-12602R-PE-Cy5.5 |
| 英文名稱1 |
Rabbit Anti-phospho-PDLIM5 (Tyr251)/PE-Cy5.5 Conjugated antibody
|
| 中文名稱 |
PE-Cy5.5標(biāo)記的磷酸化PDZ和LIM結(jié)構(gòu)域結(jié)合蛋白5抗體 |
| 別 名 |
PDLIM5 (phospho Y251); p-PDLIM5 (phospho Y251); ENH;
ENH1;
Enigma homolog;
Enigma like LIM domain protein;
Enigma like PDZ and LIM domains protein;
Enigma-like PDZ and LIM domains protein;
L 9;
L9;
LIM;
PDLI5_HUMAN;
PDLIM5;
PDZ and LIM domain 5;
PDZ and LIM domain protein 5. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) |
100ul
|
| 產(chǎn)品類型 |
磷酸化抗體 |
| 研究領(lǐng)域 |
心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來(lái)源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Human, )
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
64kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthesised phosphopeptide derived from human |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Function:
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses.
Subcellular Location:
Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse > synaptosome. Cytoplasm. Detected both at presynaptic and postsynaptic sites.
Tissue Specificity:
Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.
Similarity:
Contains 3 LIM zinc-binding domains.
Contains 1 PDZ (DHR) domain.
Database links:
Entrez Gene: 10611 Human
Omim: 605904 Human
SwissProt: Q96HC4 Human
Unigene: 480311 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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